/* 
 * TrialIntel.ai - Main Stylesheet
 * Version 2.0
 * 
 * A comprehensive CSS file for the TrialIntel.ai clinical trial prediction application
 */

/* ===== Base Styles ===== */
:root {
    /* Color Palette */
    --primary-color: #2563eb;
    --primary-light: #3b82f6;
    --primary-dark: #1d4ed8;
    --secondary-color: #64748b;
    --secondary-light: #94a3b8;
    --secondary-dark: #475569;
    --success-color: #10b981;
    --warning-color: #f59e0b;
    --danger-color: #ef4444;
    --info-color: #3b82f6;
    --neutral-color: #6b7280;
    
    /* Background Colors */
    --bg-light: #f8fafc;
    --bg-white: #ffffff;
    --bg-gray: #f1f5f9;
    --bg-dark: #1e293b;
    
    /* Text Colors */
    --text-dark: #0f172a;
    --text-medium: #334155;
    --text-light: #64748b;
    --text-white: #f8fafc;
    
    /* Border Colors */
    --border-light: #e2e8f0;
    --border-medium: #cbd5e1;
    --border-dark: #94a3b8;
    
    /* Status Colors */
    --extracted-color: #22c55e;
    --missing-color: #f97316;
    --error-color: #ef4444;
    --manual-color: #3b82f6;
    
    /* Spacing */
    --spacing-xs: 0.25rem;
    --spacing-sm: 0.5rem;
    --spacing-md: 1rem;
    --spacing-lg: 1.5rem;
    --spacing-xl: 2rem;
    --spacing-xxl: 3rem;
    
    /* Border Radius */
    --radius-sm: 0.25rem;
    --radius-md: 0.5rem;
    --radius-lg: 0.75rem;
    --radius-xl: 1rem;
    
    /* Shadows */
    --shadow-sm: 0 1px 2px 0 rgba(0, 0, 0, 0.05);
    --shadow-md: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
    --shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, 0.1), 0 4px 6px -2px rgba(0, 0, 0, 0.05);
    --shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, 0.1), 0 10px 10px -5px rgba(0, 0, 0, 0.04);
    
    /* Transitions */
    --transition-fast: 0.15s ease;
    --transition-normal: 0.3s ease;
    --transition-slow: 0.5s ease;
}

* {
    box-sizing: border-box;
    margin: 0;
    padding: 0;
}

html, body {
    font-family: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif;
    font-size: 16px;
    line-height: 1.5;
    color: var(--text-dark);
    background-color: var(--bg-light);
    -webkit-font-smoothing: antialiased;
    -moz-osx-font-smoothing: grayscale;
}

h1, h2, h3, h4, h5, h6 {
    font-weight: 600;
    line-height: 1.25;
    margin-bottom: var(--spacing-md);
    color: var(--text-dark);
}

h1 {
    font-size: 2rem;
}

h2 {
    font-size: 1.75rem;
}

h3 {
    font-size: 1.5rem;
}

h4 {
    font-size: 1.25rem;
}

p {
    margin-bottom: var(--spacing-md);
}

a {
    color: var(--primary-color);
    text-decoration: none;
    transition: color var(--transition-fast);
}

a:hover {
    color: var(--primary-dark);
    text-decoration: underline;
}

button {
    cursor: pointer;
    font-family: inherit;
}

ul, ol {
    padding-left: var(--spacing-xl);
    margin-bottom: var(--spacing-md);
}

/* ===== Layout ===== */
.app-container {
    display: flex;
    flex-direction: column;
    min-height: 100vh;
}

.app-header {
    background-color: var(--bg-white);
    border-bottom: 1px solid var(--border-light);
    padding: var(--spacing-md) var(--spacing-xl);
    display: flex;
    flex-direction: column;
    align-items: center;
    box-shadow: var(--shadow-sm);
}

.logo-container {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.logo {
    height: 2.5rem;
    width: auto;
}

.header-subtitle {
    color: var(--text-light);
    font-size: 1rem;
    margin-top: var(--spacing-xs);
}

.ai-text {
    color: var(--primary-color);
}

.app-content {
    flex: 1;
    padding: var(--spacing-xl);
    max-width: 1200px;
    margin: 0 auto;
    width: 100%;
}

.app-footer {
    background-color: var(--bg-white);
    border-top: 1px solid var(--border-light);
    padding: var(--spacing-lg) var(--spacing-xl);
    margin-top: auto;
}

.footer-content {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-md);
    max-width: 1200px;
    margin: 0 auto;
}

.footer-logo {
    font-weight: 600;
    font-size: 1.25rem;
}

.footer-links {
    display: flex;
    gap: var(--spacing-lg);
}

.footer-copyright {
    color: var(--text-light);
    font-size: 0.875rem;
}

/* ===== Wizard Steps ===== */
.wizard-steps {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: var(--spacing-xl);
    position: relative;
    max-width: 900px;
    margin-left: auto;
    margin-right: auto;
    background: none;
    padding: 0;
}

.wizard-steps::before {
    content: '';
    position: absolute;
    top: 1.5rem;
    left: 0;
    right: 0;
    height: 2px;
    background-color: var(--border-medium);
    z-index: 1;
}

.step {
    display: flex;
    flex-direction: column;
    align-items: center;
    position: relative;
    z-index: 2;
    width: 16.666%;
    min-width: 120px;
}

.step-number {
    width: 2.5rem;
    height: 2.5rem;
    border-radius: 50%;
    background-color: var(--bg-white);
    border: 2px solid var(--primary-color);
    color: var(--primary-color);
    font-size: 1.3rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    justify-content: center;
    margin-bottom: 0.5rem;
    transition: background var(--transition-fast), color var(--transition-fast);
}

.step-label {
    font-size: 1rem;
    color: var(--text-medium);
    font-weight: 500;
}

.step.active .step-number {
    background: var(--primary-color);
    color: #fff;
    border-color: var(--primary-dark);
    box-shadow: var(--shadow-md);
}

.step.completed .step-number {
    background: var(--success-color);
    color: #fff;
    border-color: var(--success-color);
}

/* Step connectors */
.wizard-steps .step:not(:last-child)::after,
.workflow-steps .step:not(:last-child)::after {
    content: '';
    position: absolute;
    top: 1.25rem;
    left: 100%;
    width: 60px;
    height: 4px;
    background: var(--border-light);
    z-index: 0;
    border-radius: 2px;
    margin-left: 10px;
}
.step.completed:not(:last-child)::after {
    background: var(--success-color);
}

/* --- Card Header Alignment for Workflow --- */
.card-header h2 {
    margin-top: 0;
    margin-bottom: var(--spacing-md);
    text-align: left;
    font-size: 1.5rem;
    font-weight: 600;
    letter-spacing: 0.01em;
    color: var(--primary-dark);
    border-left: 4px solid var(--primary-color);
    padding-left: var(--spacing-md);
    background: none;
}

/* ===== Wizard Sections ===== */
.wizard-section {
    display: none;
    animation: fadeIn var(--transition-normal);
}

.wizard-section.active {
    display: block;
}

.section-header {
    text-align: center;
    margin-bottom: var(--spacing-xl);
}

.section-header p {
    color: var(--text-light);
    max-width: 600px;
    margin-left: auto;
    margin-right: auto;
}

@keyframes fadeIn {
    from {
        opacity: 0;
        transform: translateY(10px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

/* ===== Forms ===== */
.input-form {
    max-width: 700px;
    margin: 0 auto;
    background-color: var(--bg-white);
    padding: var(--spacing-xl);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.form-group {
    margin-bottom: var(--spacing-lg);
}

label {
    display: block;
    margin-bottom: var(--spacing-sm);
    font-weight: 500;
    color: var(--text-medium);
}

.required {
    color: var(--danger-color);
}

.input-with-help {
    position: relative;
}

input[type="text"],
input[type="url"],
input[type="number"],
input[type="email"],
select,
textarea {
    width: 100%;
    padding: 0.75rem 1rem;
    border: 1px solid var(--border-medium);
    border-radius: var(--radius-md);
    font-size: 1rem;
    transition: border-color var(--transition-fast), box-shadow var(--transition-fast);
}

input:focus,
select:focus,
textarea:focus {
    border-color: var(--primary-color);
    box-shadow: 0 0 0 2px var(--primary-light);
    outline: none;
}

.tooltip-icon {
    position: absolute;
    right: var(--spacing-md);
    top: 50%;
    transform: translateY(-50%);
    color: var(--text-light);
    cursor: help;
}

.tooltip-text {
    visibility: hidden;
    width: 240px;
    background-color: var(--bg-dark);
    color: var(--text-white);
    text-align: center;
    border-radius: var(--radius-md);
    padding: var(--spacing-md);
    position: absolute;
    z-index: 10;
    bottom: 125%;
    left: 50%;
    transform: translateX(-50%);
    opacity: 0;
    transition: opacity var(--transition-normal);
    font-size: 0.875rem;
    font-weight: normal;
    box-shadow: var(--shadow-lg);
}

.tooltip-text::after {
    content: "";
    position: absolute;
    top: 100%;
    left: 50%;
    margin-left: -5px;
    border-width: 5px;
    border-style: solid;
    border-color: var(--bg-dark) transparent transparent transparent;
}

.tooltip-icon:hover .tooltip-text {
    visibility: visible;
    opacity: 1;
}

.form-actions {
    margin-top: var(--spacing-xl);
    display: flex;
    justify-content: flex-end;
}

.step-actions {
    display: flex;
    justify-content: space-between;
    margin-top: var(--spacing-xl);
}

/* ===== Buttons ===== */
.btn {
    border-radius: var(--radius-lg);
    padding: 0.75rem 2rem;
    font-size: 1.1rem;
    font-weight: 600;
    border: none;
    box-shadow: var(--shadow-sm);
    transition: background var(--transition-fast), box-shadow var(--transition-fast);
}

.btn-primary {
    background: linear-gradient(90deg, var(--primary-color), var(--primary-light));
    color: #fff;
}

.btn-primary:hover {
    background: linear-gradient(90deg, var(--primary-dark), var(--primary-color));
    box-shadow: var(--shadow-md);
}

.btn-secondary {
    background: var(--secondary-color);
    color: #fff;
}

.btn-secondary:hover {
    background: var(--secondary-dark);
    box-shadow: var(--shadow-md);
}

.btn-edit,
.btn-save {
    background: none;
    border: none;
    color: var(--text-light);
    cursor: pointer;
    transition: color var(--transition-fast);
}

.btn-edit:hover {
    color: var(--primary-color);
}

.btn-save {
    color: var(--success-color);
}

.btn-save:hover {
    color: var(--success-color);
    opacity: 0.8;
}

/* ===== Extraction Status ===== */
.extraction-status {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.status-card {
    display: flex;
    align-items: center;
    gap: var(--spacing-lg);
    background-color: var(--bg-white);
    padding: var(--spacing-lg);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.status-icon {
    width: 3rem;
    height: 3rem;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    background-color: var(--bg-gray);
    color: var(--text-light);
}

.status-icon.success {
    background-color: var(--success-color);
    color: var(--text-white);
}

.status-icon.error {
    background-color: var(--danger-color);
    color: var(--text-white);
}

.status-icon.warning {
    background-color: var(--warning-color);
    color: var(--text-white);
}

.status-details {
    flex: 1;
}

.status-details h3 {
    margin-bottom: var(--spacing-xs);
}

.status-message {
    color: var(--text-light);
    margin-bottom: var(--spacing-sm);
}

.progress-bar {
    height: 8px;
    background-color: var(--bg-gray);
    border-radius: var(--radius-sm);
    overflow: hidden;
}

.progress {
    height: 100%;
    background-color: var(--primary-color);
    transition: width var(--transition-normal);
}

.extraction-summary {
    background-color: var(--bg-white);
    padding: var(--spacing-lg);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-top: var(--spacing-xl);
}

.summary-stats {
    display: flex;
    justify-content: space-around;
    margin-top: var(--spacing-md);
}

.stat-card {
    text-align: center;
}

.stat-value {
    font-size: 2rem;
    font-weight: 600;
    color: var(--primary-color);
}

.stat-label {
    color: var(--text-light);
    font-size: 0.875rem;
}

/* ===== Validation Tabs ===== */
.validation-tabs {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    overflow: hidden;
    margin-bottom: var(--spacing-xl);
}

.tab-header {
    display: flex;
    background-color: var(--bg-gray);
    border-bottom: 1px solid var(--border-light);
}

.tab {
    padding: var(--spacing-md) var(--spacing-lg);
    cursor: pointer;
    font-weight: 500;
    transition: all var(--transition-fast);
    border-bottom: 2px solid transparent;
}

.tab.active {
    background-color: var(--bg-white);
    border-bottom-color: var(--primary-color);
    color: var(--primary-color);
}

.tab-content {
    padding: var(--spacing-lg);
}

.tab-pane {
    display: none;
}

.tab-pane.active {
    display: block;
    animation: fadeIn var(--transition-normal);
}

.validation-status {
    margin-bottom: var(--spacing-lg);
}

.status-indicator {
    display: inline-flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-sm) var(--spacing-md);
    border-radius: var(--radius-md);
    font-size: 0.875rem;
    font-weight: 500;
}

.status-indicator i {
    font-size: 1rem;
}

#phase3-validation-status {
    background-color: rgba(245, 158, 11, 0.1);
    color: var(--warning-color);
}

#phase2-validation-status {
    background-color: rgba(16, 185, 129, 0.1);
    color: var(--success-color);
}

#paper-validation-status {
    background-color: rgba(239, 68, 68, 0.1);
    color: var(--danger-color);
}

/* ===== Accordion ===== */
.accordion {
    border: 1px solid var(--border-light);
    border-radius: var(--radius-md);
    overflow: hidden;
}

.accordion-item {
    border-bottom: 1px solid var(--border-light);
}

.accordion-item:last-child {
    border-bottom: none;
}

.accordion-header {
    display: flex;
    align-items: center;
    padding: var(--spacing-md) var(--spacing-lg);
    cursor: pointer;
    background-color: var(--bg-gray);
    transition: background-color var(--transition-fast);
}

.accordion-header:hover {
    background-color: var(--bg-light);
}

.section-title {
    font-weight: 600;
    flex: 1;
}

.section-status {
    margin-right: var(--spacing-md);
    font-size: 0.875rem;
    color: var(--text-light);
}

.status-complete {
    color: var(--success-color);
}

.accordion-icon {
    transition: transform var(--transition-fast);
}

.accordion-item.active .accordion-icon {
    transform: rotate(180deg);
}

.accordion-content {
    display: none;
    padding: var(--spacing-lg);
    background-color: var(--bg-white);
}

.accordion-item.active .accordion-content {
    display: block;
}

/* ===== Validation Fields ===== */
.validation-fields {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.field-row {
    display: flex;
    align-items: center;
    padding: var(--spacing-sm) 0;
    border-bottom: 1px solid var(--border-light);
}

.field-label {
    width: 30%;
    font-weight: 500;
    padding-right: var(--spacing-md);
}

.field-value {
    flex: 1;
    padding: var(--spacing-sm) var(--spacing-md);
    border-radius: var(--radius-sm);
}

.field-value.extracted {
    background-color: rgba(34, 197, 94, 0.1);
    border-left: 3px solid var(--extracted-color);
}

.field-value.missing {
    background-color: rgba(249, 115, 22, 0.1);
    border-left: 3px solid var(--missing-color);
}

.field-value.error {
    background-color: rgba(239, 68, 68, 0.1);
    border-left: 3px solid var(--error-color);
}

.field-value.manual {
    background-color: rgba(59, 130, 246, 0.1);
    border-left: 3px solid var(--manual-color);
}

.field-actions {
    width: 40px;
    text-align: center;
}

.inline-edit {
    width: 100%;
    padding: var(--spacing-xs) var(--spacing-sm);
    border: 1px solid var(--border-medium);
    border-radius: var(--radius-sm);
}

/* ===== Validation Summary ===== */
.validation-summary {
    background-color: var(--bg-white);
    padding: var(--spacing-lg);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-top: var(--spacing-xl);
}

.summary-content {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.summary-item {
    display: flex;
    align-items: center;
}

.summary-label {
    width: 150px;
    font-weight: 500;
}

/* ===== Comparison Analysis ===== */
.comparison-container {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    padding: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.comparison-controls {
    display: flex;
    justify-content: space-between;
    margin-bottom: var(--spacing-lg);
    padding-bottom: var(--spacing-md);
    border-bottom: 1px solid var(--border-light);
}

.filter-controls {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.view-controls {
    display: flex;
    gap: var(--spacing-sm);
}

.btn-view {
    padding: var(--spacing-sm) var(--spacing-md);
    border-radius: var(--radius-md);
    border: 1px solid var(--border-medium);
    background-color: var(--bg-white);
    transition: all var(--transition-fast);
}

.btn-view.active {
    background-color: var(--primary-color);
    color: var(--text-white);
    border-color: var(--primary-color);
}

.comparison-table-container {
    overflow-x: auto;
    margin-bottom: var(--spacing-lg);
}

.comparison-table {
    width: 100%;
    border-collapse: collapse;
}

.comparison-table th {
    background-color: var(--bg-gray);
    padding: var(--spacing-md);
    text-align: left;
    font-weight: 600;
    border-bottom: 2px solid var(--border-medium);
}

.comparison-table td {
    padding: var(--spacing-md);
    border-bottom: 1px solid var(--border-light);
    vertical-align: top;
}

.comparison-table tr:hover {
    background-color: var(--bg-gray);
}

.critical-difference {
    background-color: rgba(239, 68, 68, 0.05);
}

.notable-difference {
    background-color: rgba(249, 115, 22, 0.05);
}

.impact {
    display: flex;
    align-items: flex-start;
    gap: var(--spacing-sm);
    font-size: 0.875rem;
}

.impact.positive {
    color: var(--success-color);
}

.impact.negative {
    color: var(--danger-color);
}

.impact.neutral {
    color: var(--neutral-color);
}

.comparison-summary {
    margin-top: var(--spacing-xl);
}

.insights-list {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
    margin-top: var(--spacing-md);
}

.insight-item {
    display: flex;
    gap: var(--spacing-md);
    padding: var(--spacing-md);
    border-radius: var(--radius-md);
}

.insight-item.critical {
    background-color: rgba(239, 68, 68, 0.1);
}

.insight-item.warning {
    background-color: rgba(249, 115, 22, 0.1);
}

.insight-item.positive {
    background-color: rgba(16, 185, 129, 0.1);
}

.insight-icon {
    font-size: 1.5rem;
}

.insight-item.critical .insight-icon {
    color: var(--danger-color);
}

.insight-item.warning .insight-icon {
    color: var(--warning-color);
}

.insight-item.positive .insight-icon {
    color: var(--success-color);
}

.insight-title {
    font-weight: 600;
    margin-bottom: var(--spacing-xs);
}

.insight-description {
    font-size: 0.875rem;
    color: var(--text-medium);
}

/* ===== Safety Analysis ===== */
.safety-overview {
    margin-bottom: var(--spacing-xl);
}

.safety-summary-card {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    padding: var(--spacing-lg);
}

.safety-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: var(--spacing-md);
    padding-bottom: var(--spacing-md);
    border-bottom: 1px solid var(--border-light);
}

.safety-level {
    display: flex;
    flex-direction: column;
    align-items: flex-end;
    gap: var(--spacing-xs);
}

.level-label {
    font-weight: 600;
    font-size: 0.875rem;
}

.safety-level.low .level-label {
    color: var(--success-color);
}

.safety-level.moderate .level-label {
    color: var(--warning-color);
}

.safety-level.high .level-label {
    color: var(--danger-color);
}

.level-indicator {
    width: 150px;
    height: 8px;
    background-color: var(--bg-gray);
    border-radius: var(--radius-sm);
    overflow: hidden;
}

.level-bar {
    height: 100%;
    border-radius: var(--radius-sm);
}

.safety-level.low .level-bar {
    background-color: var(--success-color);
}

.safety-level.moderate .level-bar {
    background-color: var(--warning-color);
}

.safety-level.high .level-bar {
    background-color: var(--danger-color);
}

.safety-content {
    color: var(--text-medium);
}

.impact-statement {
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
    margin-top: var(--spacing-md);
    padding-top: var(--spacing-md);
    border-top: 1px solid var(--border-light);
}

.impact-icon {
    font-size: 1.25rem;
    color: var(--primary-color);
}

.impact-value {
    font-weight: 600;
}

.impact-value.negative {
    color: var(--danger-color);
}

.impact-value.positive {
    color: var(--success-color);
}

.safety-details {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    overflow: hidden;
}

.safety-tabs {
    display: flex;
    flex-direction: column;
}

.adverse-events-summary {
    display: flex;
    flex-wrap: wrap;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-lg);
}

.events-chart {
    flex: 1;
    min-width: 300px;
}

.chart-container {
    margin-top: var(--spacing-md);
}

.chart-placeholder {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.bar-item {
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
}

.bar-label {
    width: 100px;
    text-align: right;
    font-size: 0.875rem;
}

.bar-container {
    flex: 1;
    height: 20px;
    background-color: var(--bg-gray);
    border-radius: var(--radius-sm);
    position: relative;
}

.bar {
    height: 100%;
    background-color: var(--primary-color);
    border-radius: var(--radius-sm);
}

.bar-value {
    position: absolute;
    right: var(--spacing-sm);
    top: 50%;
    transform: translateY(-50%);
    font-size: 0.75rem;
    font-weight: 600;
    color: var(--text-dark);
}

.events-table-container {
    margin-top: var(--spacing-lg);
}

.events-table {
    width: 100%;
    border-collapse: collapse;
}

.events-table th {
    background-color: var(--bg-gray);
    padding: var(--spacing-sm) var(--spacing-md);
    text-align: left;
    font-weight: 600;
    font-size: 0.875rem;
}

.events-table td {
    padding: var(--spacing-sm) var(--spacing-md);
    border-bottom: 1px solid var(--border-light);
    font-size: 0.875rem;
}

.severity {
    font-weight: 600;
    padding: var(--spacing-xs) var(--spacing-sm);
    border-radius: var(--radius-sm);
    display: inline-block;
    text-align: center;
}

.severity.high {
    background-color: rgba(239, 68, 68, 0.1);
    color: var(--danger-color);
}

.severity.medium {
    background-color: rgba(249, 115, 22, 0.1);
    color: var(--warning-color);
}

.severity.low {
    background-color: rgba(16, 185, 129, 0.1);
    color: var(--success-color);
}

.signals-list {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.signal-card {
    border-radius: var(--radius-md);
    overflow: hidden;
}

.signal-card.high {
    border: 1px solid rgba(239, 68, 68, 0.3);
}

.signal-card.medium {
    border: 1px solid rgba(249, 115, 22, 0.3);
}

.signal-card.low {
    border: 1px solid rgba(16, 185, 129, 0.3);
}

.signal-header {
    padding: var(--spacing-sm) var(--spacing-md);
}

.signal-card.high .signal-header {
    background-color: rgba(239, 68, 68, 0.1);
}

.signal-card.medium .signal-header {
    background-color: rgba(249, 115, 22, 0.1);
}

.signal-card.low .signal-header {
    background-color: rgba(16, 185, 129, 0.1);
}

.signal-severity {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    font-size: 0.875rem;
    font-weight: 600;
}

.signal-card.high .signal-severity {
    color: var(--danger-color);
}

.signal-card.medium .signal-severity {
    color: var(--warning-color);
}

.signal-card.low .signal-severity {
    color: var(--success-color);
}

.signal-content {
    padding: var(--spacing-md);
}

.signal-content h4 {
    margin-bottom: var(--spacing-sm);
}

.signal-content p {
    font-size: 0.875rem;
    color: var(--text-medium);
    margin-bottom: var(--spacing-sm);
}

.signal-source {
    font-size: 0.75rem;
    color: var(--text-light);
    font-style: italic;
}

.mechanism-info {
    display: flex;
    flex-wrap: wrap;
    gap: var(--spacing-lg);
}

.drug-info-card {
    background-color: var(--bg-gray);
    padding: var(--spacing-md);
    border-radius: var(--radius-md);
    min-width: 250px;
}

.info-row {
    display: flex;
    margin-bottom: var(--spacing-sm);
}

.info-label {
    width: 100px;
    font-weight: 500;
}

.concerns-list {
    flex: 1;
    min-width: 300px;
}

.concern-item {
    display: flex;
    align-items: flex-start;
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-md);
    padding-bottom: var(--spacing-md);
    border-bottom: 1px solid var(--border-light);
}

.concern-item:last-child {
    border-bottom: none;
}

.concern-icon {
    font-size: 1.25rem;
    color: var(--warning-color);
}

.concern-title {
    font-weight: 500;
    margin-bottom: var(--spacing-xs);
}

.concern-source {
    font-size: 0.75rem;
    color: var(--text-light);
    font-style: italic;
}

.safety-recommendations {
    padding: var(--spacing-lg);
    border-top: 1px solid var(--border-light);
}

.recommendations-list {
    list-style: none;
    padding: 0;
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.recommendations-list li {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.recommendations-list i {
    color: var(--success-color);
}

/* ===== Prediction Results ===== */
.prediction-container {
    display: flex;
    flex-wrap: wrap;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

.prediction-card {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    padding: var(--spacing-lg);
    flex: 1;
    min-width: 300px;
}

.prediction-header {
    margin-bottom: var(--spacing-lg);
    text-align: center;
}

.prediction-result {
    display: flex;
    flex-direction: column;
    align-items: center;
}

.probability-gauge {
    display: flex;
    flex-direction: column;
    align-items: center;
}

.gauge-value {
    font-size: 3rem;
    font-weight: 700;
    color: var(--primary-color);
    margin-bottom: var(--spacing-md);
}

.gauge-visualization {
    position: relative;
    width: 200px;
    height: 100px;
    margin-bottom: var(--spacing-md);
}

.gauge-circle {
    position: absolute;
    width: 200px;
    height: 200px;
    bottom: 0;
    border-radius: 100%;
    overflow: hidden;
}

.gauge-fill {
    position: absolute;
    top: 0;
    left: 0;
    width: 200px;
    height: 200px;
    transform-origin: center bottom;
    background-color: var(--primary-color);
}

.gauge-center {
    position: absolute;
    width: 160px;
    height: 160px;
    bottom: 0;
    left: 20px;
    border-radius: 100%;
    background-color: var(--bg-white);
}

.confidence-interval {
    font-size: 1rem;
    color: var(--text-light);
    margin-top: var(--spacing-md);
}

.key-insights-card {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    padding: var(--spacing-lg);
    flex: 1;
    min-width: 300px;
}

.insights-header {
    margin-bottom: var(--spacing-lg);
}

.insights-content {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.insight-item {
    display: flex;
    gap: var(--spacing-md);
    align-items: flex-start;
}

.insight-icon {
    width: 24px;
    height: 24px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 0.875rem;
}

.insight-icon.positive {
    background-color: rgba(16, 185, 129, 0.1);
    color: var(--success-color);
}

.insight-icon.negative {
    background-color: rgba(239, 68, 68, 0.1);
    color: var(--danger-color);
}

.insight-icon.neutral {
    background-color: rgba(107, 114, 128, 0.1);
    color: var(--neutral-color);
}

.calculation-details {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    margin-bottom: var(--spacing-xl);
    overflow: hidden;
}

.calculation-header {
    padding: var(--spacing-md) var(--spacing-lg);
    display: flex;
    justify-content: space-between;
    align-items: center;
    background-color: var(--bg-gray);
    border-bottom: 1px solid var(--border-light);
    cursor: pointer;
}

.btn-toggle-calculation {
    background: none;
    border: none;
    color: var(--text-medium);
    cursor: pointer;
    transition: transform var(--transition-fast);
}

.calculation-content {
    padding: var(--spacing-lg);
    display: none;
}

.calculation-details.active .calculation-content {
    display: block;
}

.calculation-details.active .btn-toggle-calculation {
    transform: rotate(180deg);
}

.calculation-steps {
    margin-bottom: var(--spacing-lg);
}

.calculation-steps ol {
    padding-left: var(--spacing-xl);
}

.calculation-steps li {
    margin-bottom: var(--spacing-sm);
}

.calculation-assumptions ul {
    padding-left: var(--spacing-xl);
}

.report-actions {
    display: flex;
    justify-content: center;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-xl);
}

/* ===== Utilities ===== */
.hidden {
    display: none !important;
}

/* ===== Loading Overlay ===== */
.loading-overlay {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background-color: rgba(0, 0, 0, 0.5);
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    z-index: 1000;
}

.loading-spinner {
    border: 6px solid var(--border-light);
    border-top: 6px solid var(--primary-color);
    border-radius: 50%;
    width: 48px;
    height: 48px;
    animation: spin 1s linear infinite;
    margin: 0 auto var(--spacing-md) auto;
}

.loading-message {
    color: var(--text-white);
    font-weight: 500;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

/* ===== Modal ===== */
.modal {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background-color: rgba(0, 0, 0, 0.5);
    display: flex;
    align-items: center;
    justify-content: center;
    z-index: 1000;
}

.modal-content {
    background-color: var(--bg-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-xl);
    width: 90%;
    max-width: 500px;
    max-height: 90vh;
    overflow-y: auto;
}

.modal-header {
    padding: var(--spacing-md) var(--spacing-lg);
    border-bottom: 1px solid var(--border-light);
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.modal-close {
    background: none;
    border: none;
    font-size: 1.25rem;
    color: var(--text-light);
    cursor: pointer;
    transition: color var(--transition-fast);
}

.modal-close:hover {
    color: var(--danger-color);
}

.modal-body {
    padding: var(--spacing-lg);
}

.modal-footer {
    padding: var(--spacing-md) var(--spacing-lg);
    border-top: 1px solid var(--border-light);
    display: flex;
    justify-content: flex-end;
    gap: var(--spacing-md);
}

/* ===== Modern Card & Modal Enhancements ===== */
.card, .modal-container {
    border-radius: var(--radius-xl);
    box-shadow: var(--shadow-lg);
    background: linear-gradient(135deg, var(--bg-white) 80%, var(--bg-gray) 100%);
    border: 1px solid var(--border-light);
    margin-bottom: var(--spacing-xl);
    padding: var(--spacing-lg) var(--spacing-xl);
    transition: box-shadow var(--transition-normal);
}
.card:hover, .modal-container:hover {
    box-shadow: var(--shadow-xl);
}

/* ===== Typography & Spacing ===== */
h1, h2, h3 {
    letter-spacing: -0.5px;
}
.card-header h2 {
    font-size: 2rem;
    margin-bottom: var(--spacing-md);
}
.card-body {
    font-size: 1.1rem;
    color: var(--text-medium);
}

/* ===== Responsive Design ===== */
@media (max-width: 900px) {
    .main, .container, .app-content {
        padding: var(--spacing-md);
    }
    .wizard-steps, .workflow-steps {
        gap: var(--spacing-md);
    }
    .card, .modal-container {
        padding: var(--spacing-md);
    }
}
@media (max-width: 600px) {
    .wizard-steps, .workflow-steps {
        flex-direction: column;
        gap: var(--spacing-sm);
    }
    .step {
        min-width: 60px;
    }
    .card, .modal-container {
        padding: var(--spacing-sm);
    }
    .form-actions {
        flex-direction: column;
        gap: var(--spacing-sm);
    }
}

/* ===== Toast Notification (for future use) ===== */
.toast {
    position: fixed;
    bottom: 2rem;
    right: 2rem;
    background: var(--primary-dark);
    color: #fff;
    padding: 1rem 2rem;
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-lg);
    z-index: 9999;
    opacity: 0.95;
    font-size: 1.1rem;
    display: none;
}
.toast.show {
    display: block;
    animation: fadeInUp 0.5s;
}
@keyframes fadeInUp {
    from { opacity: 0; transform: translateY(40px); }
    to { opacity: 0.95; transform: translateY(0); }
}

/* ===== Step Content Visibility ===== */
.step-content {
    display: none;
}
.step-content.active {
    display: block;
}

/* ===== Navigation Button Group ===== */
.nav-btn-group {
  display: flex;
  flex-direction: row;
  flex-wrap: nowrap;
  gap: 0.5rem;
  overflow-x: auto;
  scrollbar-width: thin;
  scrollbar-color: #cbd5e1 #f1f5f9;
  -webkit-overflow-scrolling: touch;
}

.nav-btn {
  display: inline-block;
  white-space: nowrap;
  padding: 0.6rem 1.5rem;
  border-radius: 2rem;
  background: #f1f5f9;
  color: #2563eb;
  font-weight: 600;
  font-size: 1.05rem;
  text-decoration: none;
  transition: background 0.18s, color 0.18s;
  border: none;
  box-shadow: none;
}

.nav-btn:hover, .nav-btn:focus {
  background: linear-gradient(90deg,#2563eb,#3b82f6);
  color: #fff;
}

@media (max-width: 900px) {
  .nav-btn-group {
    gap: 0.3rem;
  }
  .nav-btn {
    padding: 0.5rem 1.1rem;
    font-size: 0.98rem;
  }
}

@media (max-width: 600px) {
  .nav-btn-group {
    gap: 0.2rem;
  }
  .nav-btn {
    padding: 0.45rem 0.8rem;
    font-size: 0.93rem;
  }
}